Method development to quantify Bv8 expression in circulating CD11b+ cells in patients with neovascular age-related macular degeneration (nvAMD) exhibiting Anti-VEGF refractoriness
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- 作者：Timothy Catchpolea ; tcatch@retinafoundation.org" class="auth_mail" title="E-mail the corresponding author ; Tad Danielsa ; Jill Perkinsa ; Karl G. Csakya ; b ; c
- 关键词：Neovascular age-related macular degeneration ; Prokineticin-2 (Bv8) ; Anti-VEGF refractoriness ; Gene expression
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：45-51
- 全文大小：672 K
文摘
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A technique of assaying gene expression in sets of circulating cells in nvAMD patients is developed.
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The assay is shown to have good reproducibility and low intra-patient variability.
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A link between Bv8 expression in CD11b + cells and nvAMD treatment response is investigated.