Diosgenin regulates adipokine expression in perivascular adipose tissue and ameliorates endothelial dysfunction via regulation of AMPK
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- 作者：Yan Chena ; Xiaoshan Xub ; Yuanyuan Zhanga ; Kang Liub ; Fang Huangb ; Baolin Liub ; 1 ; zhongyao440@163.com" class="auth_mail" title="E-mail the corresponding author ; Junping Koua ; junpingkou@cpu.educn" class="auth_mail" title="E-mail the corresponding author ; junpingkou@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diosgenin ; Perivascular adipose tissue ; AMPK ; Inflammation ; Endothelial dysfunction
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：155
- 期：part_PA
- 页码：155-165
- 全文大小：2547 K
文摘
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Diosgenin modulates adipokine expression in PVAT against inflammation.
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The anti-inflammatory activity of diosgenin in PVAT depends on AMPK.
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Protecting PVAT function by diosgenin prevents endothelial dysfunction.