Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa
详细信息 查看全文
- 作者：Teresa Domí ; nguez-Gil1 ; Mijoon Lee2 ; Ivá ; n Acebró ; n-Avalos1 ; Kiran V. Mahasenan2 ; Dusan Hesek2 ; David A. Dik2 ; Byungjin Byun2 ; Elena Lastochkin2 ; Jed F. Fisher2 ; Shahriar Mobashery2 ; mobashery@nd.edu" class="auth_mail" title="E-mail the corresponding author ; Juan A. Hermoso1 ; 3 ; xjuan@iqfr.csic.es" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：24
- 期：10
- 页码：1729-1741
- 全文大小：5241 K
文摘
- •
Modular LT having a catalytic module and an ABC-transporter-like regulatory module
- •
Both regulatory module and the linker region keep MltF in an inactive conformation
- •
Muropeptide binding at regulatory module triggers MltF activation
- •
First case of allosteric regulation in an LT spurred by dramatic structural changes