Aggregation of PEGylated liposomes driven by hydrophobic forces
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- 作者：Tamá ; s Bozó ; a ; 1 ; bozo.tamas@med.semmelweis-univ.hu" class="auth_mail" title="E-mail the corresponding author ; Tamá ; s Mé ; szá ; rosb ; c ; 1 ; tmeszaros@seroscience.com" class="auth_mail" title="E-mail the corresponding author ; Judith Mihá ; lyd ; mihaly.judith@ttk.mta.hu" class="auth_mail" title="E-mail the corresponding author ; Attila Bó ; tad ; bota.attila@ttk.mta.hu" class="auth_mail" title="E-mail the corresponding author ; Mikló ; s S.Z. Kellermayera ; e ; miklos.kellermayer@med.semmelweis-univ.hu" class="auth_mail" title="E-mail the corresponding author ; Já ; nos Szebenib ; c ; jszebeni2@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Benedek Ká ; lmá ; nb
- 关键词：Liposome ; PEG ; Aggregation ; Fusion ; Hydrophobic effect ; Ammonium sulfate ; Kosmotropic salt
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：467-474
- 全文大小：2631 K
文摘
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Kosmotropes induce the aggregation and fusion of PEG-liposomes.
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The effect depends on both the kosmotrope and PEG concentration.
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Aggregation is reversible under certain conditions.
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Kosmotropes lead to a dehydration-related conformational change of the PEG polymer.
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The likely driving force behind aggregation is the hydrophobic effect.