New perspectives in the treatment of obstructive sleep apnea-hypopnea syndrome

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• 作者：Edgar Corté ; s-Reyes^a ; ^{ecortesr@unal.edu.co} ; Katherine Parrado-Bermú ; dez^a ; Franklin Escobar-C&oacute ; rdoba^b ; ^c
• 关键词：Sleep apnea syndromes ; Obesity ; Comorbidity ; Therapeutics ; Airway obstruction
• 刊名：Colombian Journal of Anesthesiology
• 出版年：2017
• 出版时间：January-March 2017
• 年：2017
• 卷：45
• 期：1
• 页码：62-71
• 全文大小：1428 K
• 卷排序：45

文摘

Obstructive sleep apnea–hypopnea syndrome (OSA) is an increasingly prevalent disorder in the population, which seriously compromises the quality of life of sufferers. Although continuous positive airway pressure remains the most commonly used treatment modality, its poor adhesion and relative failure have provoked several studies seeking to develop more convenient and effective alternatives for treating this condition.ObjectiveTo review the most effective, recent and innovative strategies that scientific evidence suggests for the treatment of OSA from anatomical and physiological mechanisms involved.Materials and methodsA literature review was performed from items taken from PubMed, ScienceDirect, Springer, LILACS and PEDro databases, published between 2005 and 2015 in English.ResultsOSA is an intermittent and repetitive obstruction of the upper airway during sleep, caused mainly by an imbalance in respiratory muscle synergy. For treatment, the scientific literature has recently described methods such as oral devices, oral and nasal pressure therapies, Pillar, the Night Shift, bariatric surgery and stimulation of the hypoglossal nerve.ConclusionsAlthough a fully effective treatment is not yet available, a combination of strategies from an interdisciplinary perspective can enhance the quality of life of patients. It is expected that in the coming years, the scientific and technological advances will allow for the implementation of a treatment protocol that is able to directly address the etiological processes to reduce their prevalence.