Arctigenin reduces neuronal responses in the somatosensory cortex via the inhibition of non-NMDA glutamate receptors
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- 作者：Sá ; ndor Borbé ; lya ; Gergely Jó ; csá ; ka ; Kinga Moldová ; na ; É ; va Sedlá ; kb ; É ; va Preiningerb ; Imre Boldizsá ; rb ; Attila Tó ; tha ; Palmi T. Atlasonc ; Elek Molná ; rc ; Ildikó ; Vilá ; gia ; vilagildi@ttk.elte.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arctigenin ; Ionotropic glutamate receptors ; Evoked field potentials ; Rat ; Brain slices ; In vivo experiments
- 刊名：Neurochemistry International
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：97
- 期：Complete
- 页码：83-90
- 全文大小：1002 K
文摘
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Biologically active compounds, like arctigenin, a lignan produced by different plants may have neuroprotective effects.
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Arctigenin effectively reduces normal, physiological electrical responses both in brain slices and in whole brain.
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Arctigenin can cross the blood-brain barrier and it may exerts effect on nervous system of living animals.
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Arctigenin effectively binds to GluK1 subunit of kainate receptors.
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Different AMPA/KAIN types of ionotropic glutamate receptors may possess arctigenin binding properties.