Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress

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• 作者：Begoñ ; a Quintana-Villamandos^a ; ^{begoquinti@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Marí ; a Carmen Gonzá ; lez^b ; ^{m.c.gonzalez@uam.es" class="auth_mail" title="E-mail the corresponding author} ; Marí ; a Jesú ; s Delgado-Martos^c ; ^{mj.delgadomartos@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Luis Condezo-Hoyos^b ; ^{lcondezotm@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Rainer H. Bö ; ger^d ; ^{boeger@uke.uni-hamburg.de" class="auth_mail" title="E-mail the corresponding author} ; Nicole Lü ; neburg^d ; ^{n.lueneburg@uke.de" class="auth_mail" title="E-mail the corresponding author} ; Laia Paz&oacute ; -Say&oacute ; s^a ; ^{lpazosay8@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Perla Yareli Gutié ; rrez-Arzapalo^b ; ^{pela.gutierrez@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Emilio Delgado-Baeza^c ; ^{delgadobaeza@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Aorta ; Asymmetrical dimethylarginine ; Esmolol ; Hypertension ; Spontaneously hypertensive rats ; Vascular remodeling
• 刊名：European Journal of Pharmacology
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：791
• 期：Complete
• 页码：502-509
• 全文大小：1555 K

文摘

Esmolol produces early regression of left ventricular hypertrophy and improves coronary artery remodeling, although the impact of short-term treatment with this beta-blocker on remodeling in large arteries has not yet been studied. We hypothesized that even a short (48 h) course of esmolol might alter remodeling of the aorta in the spontaneously hypertensive rat (SHR). Fourteen-month-old male SHRs were treated intravenously with vehicle (SHR, n=8) or esmolol (SHR-E, n=8) (300 μg/kg/min). Age-matched, vehicle-treated male Wistar-Kyoto rats (WKY, n=8) served as controls. After 48 h, we studied the structure, volume density of elastic fibers, and passive mechanical properties of the aorta. Determination of asymmetrical dimethylarginine concentrations and total protein carbonyls in the aorta were analyzed. Esmolol significantly attenuated abnormal aortic wall thickness, cross-sectional area, wall-to-lumen ratio, volume density of elastic fibers, and wall stiffness. The protective effect of esmolol could be related to a decrease in asymmetrical dimethylarginine levels after down-regulation by oxidative stress. These findings could play a key role in the selection of antihypertensive therapy in patients with hypertension and aortic remodeling.