Brain inflammation, neurodegeneration and seizure development following picornavirus infection markedly differ among virus and mouse strains and substrains
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- 作者：Sonja Brö ; era ; Christopher Kä ; ufera ; b ; Verena Haistc ; 1 ; Lin Lib ; c ; Ingo Gerhauserc ; Muneeb Anjuma ; b ; Marion Bankstahla ; b ; Wolfgang Baumgä ; rtnerb ; c ; Wolfgang Lö ; schera ; b ; wolfgang.loescher@tiho-hannover.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：B6 ; C57BL/6 ; B6H ; C57BL/6JOlaHsd ; B6J ; C57BL/6J ; CNS ; central nervous system ; DA ; Daniel's ; DG ; dentate gyrus ; dpi ; days post-infection ; EEG ; electroencephalogram ; IFN ; interferon ; IL ; interleukin ; ISG ; interferon-stimulated gene ; NK ; natural killer ; OAS1 ; 2&prime ; 5&prime ; -oligoadenylate synthetase 1 ; PFU ; plaque-forming units ; pi ; post-infection ; PKR ; protein kinase R ; PMN ; polymorphonuclear leukocyte ; ROC ; receiver operating characteristic ; TCS ; total clinical score ; TMEV ; Theiler's murine enc
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：279
- 期：Complete
- 页码：57-74
- 全文大小：2895 K
文摘
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Brain infection of C57BL/6 (B6) mice with Theiler's virus (TMEV) induces epilepsy.
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We examined the response of two B6 substrains to three different TMEV (sub)strains.
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Receiver operating characteristic (ROC) curve analysis was used for correlations.
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Early and late seizures were observed with DA and a BeAn substrain of TMEV virus.
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Markers of hippocampal inflammation and neurodegeneration correlated with ictogenesis.