Association between polymorphisms in OAS2 and CD209 genes and predisposition to chronic hepatitis C in Russian population

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• 作者：Andrey V. Barkhash^a ; ^{barkhash@bionet.nsc.ru" class="auth_mail} ; Galina V. Kochneva^b ; Elena V. Chub^b ; Svetlana V. Mikhailova^a ; Aida G. Romaschenko^a
• 关键词：Chronic hepatitis C ; Genetic predisposition to disease ; Single nucleotide polymorphism
• 刊名：Microbes and Infection
• 出版年：May 2014
• 年：2014
• 卷：16
• 期：5
• 页码：445-449
• 全文大小：171 K

文摘

Chronic hepatitis C is a severe liver disease caused by positive-strand RNA virus. Previously, we reported an association between seven single nucleotide polymorphisms (SNPs) in four innate immunity genes (OAS2, OAS3, CD209, and TLR3) and human predisposition to tick-borne encephalitis, caused by a virus from the same Flaviviridae family, in a Russian population. Currently, genotype and allele frequencies for these SNPs were analyzed in 75 chronic hepatitis C patients and compared with the population control (269 Novosibirsk citizens). Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population.