Heterogeneity of blood flow and metabolism during exercise in patients with chronic obstructive pulmonary disease

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• 作者：Zafeiris Louvaris^a ; ^b ; ^c ; ^{zafeiris.louvaris@kuleuven.be} ; Helmut Habazettl^d ; ^e ; Andreas Asimakos^b ; Harrieth Wagner^f ; Spyros Zakynthinos^b ; Peter D. Wagner^f ; Ioannis Vogiatzis^a ; ^b ; ^g
• 关键词：Chronic obstructive pulmonary disease ; Muscle perfusion ; Muscle metabolism ; Exercise ; NIRS
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：237
• 期：Complete
• 页码：42-50
• 全文大小：863 K
• 卷排序：237

文摘

NIRS applied in COPD to assess the regional muscle heterogeneity of VO2, Q and their ratio. Heterogeneity for VO2 and Q progressively increased with exercise. However, VO2/Q heterogeneity remained unaffected with increased exercise. COPD tightly regulate regional muscle Q relative to VO2 during submaximal exercise. VO2/Q heterogeneity does not impact on muscle O2 availability at submaximal exercise.