The relationship between sleep apnea, metabolic dysfunction and inflammation: The gender influence

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• 作者：Camila Hirotsu¹ ; Rachel G. Albuquerque¹ ; Heloisa Nogueira ; Helena Hachul ; Lia Bittencourt ; Sergio Tufik ; Monica L. Andersen ; ^{ml.andersen12@gmail.com}
• 关键词：Sleep ; Obstructive sleep apnea ; Gender ; Sex ; Leptin ; TNF-alpha ; Ghrelin
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：211-218
• 全文大小：330 K
• 卷排序：59

文摘

OSA can differently affect respiratory sleep parameters according to gender. OSA men presented greater apnea index and lower N3 sleep stage than OSA women. Postmenopause was related to increased apnea-hypopnea index during REM in OSA women. OSA was associated with higher TNF-α in women and higher leptin levels in men. Sexual hormones may play a role in the inflammatory consequences associated with OSA.