Exploring the efficacy of a 5-day course of transcranial direct current stimulation (TDCS) on depression and memory function in patients with well-controlled temporal lobe epilepsy
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- 作者：Anli Liua ; b ; e ; Anli.liu@nyumc.org" class="auth_mail" title="E-mail the corresponding author ; Andrew Bryanta ; c ; Ashlie Jeffersona ; c ; Daniel Friedmana ; b ; Preet Minhasa ; b ; Sarah Barnarda ; b ; William Barra ; b ; Thomas Thesena ; b ; Margaret O'Connord ; f ; Mouhsin Shafid ; e ; f ; Susan Hermand ; f ; Orrin Devinskya ; b ; Alvaro Pascual-Leoned ; e ; f ; Steven Schachterd ; f
- 关键词：Temporal lobe epilepsy ; Depression ; Memory ; Transcranial direct current stimulation ; Neurostimulation ; Stimulation safety
- 刊名：Epilepsy & Behavior
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：11-20
- 全文大小：624 K
文摘
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A five-day course of TDCS has a modest but significant benefit in improving depressive symptoms in adult patients with well controlled TLE, but the effects did not persist to the 2- and 4- week follow up.
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There is no effect on delayed recall or working memory function after a 5-day course of TDCS.
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TDCS does not increase seizure frequency or interictal discharge frequency, and is well tolerated among patients.
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TDCS induced an increase in delta frequency power over the frontal region and delta, theta, and alpha power in the occipital region, immediately after stimulation, compared to sham stimulation, although this did not reach statistical significance.