Prehospital nitroglycerin administration is a safe and effective treatment option for the relief of angina. Nitroglycerin administration to patients with inferior wall myocardial infarction (IWMI) was first studied in the 1980s with small retrospective studies determining a strong link between hypotension and bradycardia and nitroglycerin administration in IWMI with or without right ventricular myocardial infarction (RVMI). More recent large retrospective studies have shown comparable rates of hypotension and bradycardia from nitroglycerin in IWMI with or without RVMI compared with non-IWMI patients. It appears safe to administer nitroglycerin to all patients independent of specific coronary artery occlusion.