In-stent restenosis leading to coronary chronic total occlusion (ISR-CTO) is an uncommon problem in clinical practice The reported incidence of ISR-CTO ranges from 5% to 10% of all CTO-PCI and the percutaneous treatment of ISR-CTO has a lower procedural success rate than conventional CTO. In this setting the use of intravascular ultrasound is of paramount importance. We describe a case of a 43-year old male patient with a long-in stent CTO of ostial right coronary artery treated with retrograde approach highlighting the importance of IVUS evaluation in the treatment of this patient.