The Risk of Intracranial Hemorrhage in Japanese Patients with Acute Large Vessel Occlusion; subanalysis of the RESCUE-Japan registry

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• 作者：Yukiko Enomoto ; MD ; PhD^* ; ^{enomoto@gifu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Shinichi Yoshimura ; MD ; PhD^&dagger ; ; Yusuke Egashira ; MD ; PhD^* ; Hiroshi Yamagami ; MD ; PhD^&Dagger ; ; Nobuyuki Sakai ; MD ; PhD^§ ; ; Committee of Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan Study Group
• 关键词：Acute stroke ; recanalization therapy ; endovascular ; intracranial hemorrhage
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：25
• 期：5
• 页码：1076-1080
• 全文大小：95 K

文摘

Recanalization therapies such as intravenous thrombolysis (IVT) or endovascular treatment (EVT) improve acute ischemic stroke outcomes; however, they carry the risk of intracranial hemorrhage (ICH). The present study assessed the frequency and predictive factor of ICH in Japanese patients with acute large vessel occlusion.

Methods

The Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism-Japan Registry prospectively registered 1442 stroke patients with major vessel occlusion who were admitted to 84 Japanese stroke centers within 24 hours after onset, from July 2010 to June 2011. Among these 1442 patients, 1357 were included to evaluate the incidence rate and predictive factors of ICH within 24 hours after onset.

Results

ICH was observed in 284 (20.9%) patients. Among these patients, 46 (3.4%) had symptomatic ICH, and its incidence was higher in the recanalization therapy (IVT and/or EVT) group than in the conservative therapy group (4.5% versus 2.1%, P = .013). On multivariate analyses, symptomatic ICH was related to pretreatment antiplatelet agent use and systemic heparinization, and was related to neither IVT nor EVT.

Conclusions

Symptomatic ICH was not affected by recanalization therapy or EVT itself in Japanese patients with acute large vessel occlusion.