Outcome after implantable cardioverter-defibrillator in patients with Brugada syndrome: the Gulf Brugada syndrome registry

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• 作者：Amin Daoulah ; FRCPC^a ; ^{amindaoulah@yahoo.com} ; Alawi A. Alsheikh-Ali ; MD ; MSc ; FACC^b ; Ali H. Ocheltree ; MBBS^a ; Sara Ocheltree ; MBBS^a ; Salem Al-Kaabi ; FRCPC^b ; Majed Malik ; MBBS^c ; Abdul-Karim Al-Habib ; MBBS^c ; Adel Hamed ; FRCPC^d ; Najib Al-Rawahi ; FRCPC ; ABIM^e ; Ali Al-Sayegh ; FRCPC ; FACC^f ; Saad Al-Hasaniah ; FRCPC^g ; Eijaz Ul-Haq ; MD^a
• 关键词：Brugada syndrome ; Implantable cardioverter-defibrillator ; Sudden cardiac death ; Tachyarrhythmias ; Electrophysiologic study
• 刊名：Journal of Electrocardiology
• 出版年：2012
• 出版时间：May-June, 2012
• 年：2012
• 卷：45
• 期：3
• 页码：327-332
• 全文大小：764 K

文摘

Background and Objective

Among patients with Brugada syndrome (BS) and aborted cardiac arrest, syncope, or inducible ventricular fibrillation at electrophysiologic study (EPS), the only currently recommended therapy is an implantable cardioverter-defibrillator (ICD), but these are not without complications. We assessed the total number of shocks (appropriate and inappropriate) and complications related to ICD in patients with BS.

Methods and Results

Twenty-five patients implanted with ICD for BS in 6 Gulf centers between January 1, 2002, and December 31, 2010, were reviewed. Implantable cardioverter-defibrillator indication was based on aborted cardiac arrest (24 % ), syncope (56 % ), or in asymptomatic patients with positive EPS (20 % ). During a follow-up of 41.2 ¡À 17.6 months, 3 patients (all with prior cardiac arrest) had appropriate device therapy. Four patients developed complications; 3 of them had inappropriate shocks.

Conclusion

In our cohort, appropriate device therapy was limited to cardiac arrest survivors, whereas none of those with syncope and/or positive EPS had arrhythmias. Overall complication rate was relatively high, including inappropriate ICD shocks.