What are the differences between aerobic and anaerobic toxic effects of sulfonamides on Escherichia coli?
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- 作者：Mengnan Qina ; Zhifen Lina ; b ; c ; lzhifen@tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Dali Wanga ; Xi Longa ; Min Zhenga ; Yanling Qiub
- 关键词：SAs ; sulfonamides ; EC50-anaerobic ; the median effective concentration under anaerobic conditions ; EC50-aerobic ; the median effective concentration under aerobic conditions ; ROS ; reactive oxygen species ; Ebinding ; interaction energy ; dhps ; dihydropteroate synthase ; QSAR ; quantitative structure&ndash ; activity relations ; Dow ; the pH-dependent n-octanol&ndash ; water distribution ratio ; SCP ; sulfachloropyridazine ; SD ; sulfadiazine ; SIX ; sulfisoxazole ; SM ; sulfameter ; SMM ; sulfamonomethoxine ; SMP ; sulf
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：251-258
- 全文大小：1682 K
文摘
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Both the aerobic and anaerobic toxicity of SAs to Escherichia coli were determined.
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Besides logDow and Ebinding, the key factors to anaerobic toxicity, ROS was also a key factor to aerobic toxicity.
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The different total binding energy led to SAs divided into three groups.
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This division of three groups was independent of the structures of SAs.