Tomographic examination of magnetic nanoparticles used as drug carriers
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- 作者：Helene Rahn ; Inmaculada Gomez-Morilla ; Rol ; Jurgons ; Christoph Alexiou ; Dietmar Eberbeck ; Stefan Odenbach
- 关键词：X-ray computed tomography (CT) ; Microcomputed tomography (μ ; CT) ; Local cancer treatment ; Biological tissue
- 刊名：Journal of Magnetism and Magnetic Materials
- 出版年：2009
- 出版时间：May 2009
- 年：2009
- 卷：321
- 期：10
- 页码：1517-1520
- 全文大小：398 K
文摘
Tumors grown on animals and treated with magnetic drug targeting and magnetic hyperthermia have been analyzed by microcomputed X-ray tomography to study the three-dimensional nanoparticle distribution. The measurements have been performed in two laboratories, with a polychromatic X-ray cone beam as well as with monochromatic parallel beam. Due to the poor resolution in the first case, the distribution of the magnetic nanoparticles can be studied only qualitatively. With the polychromatic beam semi-quantitative results can be achieved. In this paper, the results from both methods are presented and compared.