Non-genomic oestrogen receptor signal in B lymphocytes: An approach towards therapeutic interventions for infection, autoimmunity and cancer
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- 作者：Karsen Setoa ; Minh Hoanga ; Thaddeus Santosa ; Mausumi Bandyopadhyayc ; Mark S. Kindyd ; e ; Subhajit Dasguptaa ; b ; sdasgupta@mail.sjsm.org" class="auth_mail" title="E-mail the corresponding author ; subhajitdasgupta@outlook.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：mER ; membrane bound oestrogen receptor ; GPER ; G-protein coupled oestrogen receptor ; PIP2 ; phosphatidylinositol 4 ; 5-biphosphate ; IP3 ; inositol triphosphate ; PI3 kinase ; phosphoinositide 3-kinase ; Akt ; protein kinase B a Serine/Threonine specific protein kinase ; MAP kinase ; mitogen activated protein kinase ; mTOR ; mammalian target of rapamycin atypical Serine/Threonine kinase ; TLR ; toll-like receptor
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：115-118
- 全文大小：778 K
文摘
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Membrane bound oestrogen receptors regulate B cell signalling.
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Membrane bound PLC and PIP2/IP3 initiate B cell signalling.
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Fc receptor-like integral protein receptor modulate BCR signalling.
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BCR signalling initiates Akt, MAP kinase and mTOR pathways.
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Choice of ligands have importance on cross-talk between receptor-mediated signalling.