OGG1 is essential in oxidative stress induced DNA demethylation
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- 作者：Xiaolong Zhoua ; 1 ; Ziheng Zhuangb ; c ; 1 ; Wentao Wanga ; 1 ; Lingfeng Hea ; 1 ; Huan Wua ; Yan Caoa ; Feiyan Pana ; Jing Zhaoa ; Zhigang Hua ; Chandra Sekhara ; Zhigang Guoa ; guozgang@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：OGG1 ; 8-Oxoguanine DNA glycosylase-1 ; 8-oxoG ; 8-Oxoguanine ; ROS ; reactive oxygen species ; α-KG ; α-Ketoglutarate ; MeDIP ; methylated DNA immunoprecipitations ; 5mC ; 5-Methyl cytosine ; 5hmC ; 5-Hydroxymethyl cytosine ; 5fC ; 5-Formylcytosine ; 5caC ; 5-Carboxylcytosine ; BER ; base excision repair ; CpGs ; CpG dinucleotides ; EtdBr ; ethidium bromide ; TDG ; thymine DNA glycosylase ; UNG ; uracil-DNA glycosylase
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：28
- 期：9
- 页码：1163-1171
- 全文大小：1263 K
文摘
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OGG1 is involved in oxidative stress induced DNA demethylation.
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OGG1 binds and recruits TET1 to the 8-oxodG adjacent 5mC site.
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This manuscript illustrates the important roles of BER in DNA demethylation.