Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres
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- 作者：Laura Garcia-Exposito1 ; 6 ; Elodie Bournique4 ; 6 ; Valé ; rie Bergoglio4 ; 6 ; Arindam Bose2 ; Jonathan Barroso-Gonzalez1 ; Sufang Zhang5 ; Justin L. Roncaioli1 ; Marietta Lee5 ; Callen T. Wallace3 ; Simon C. Watkins3 ; Patricia L. Opresko2 ; Jean-Sé ; bastien Hoffmann4 ; Roderick J. O&rsquo ; Sullivan1 ; 7 ; osullivanr@upmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：telomere ; BioID ; translesion DNA synthesis ; polymerase ; mitosis ; D-loop ; cancer
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：8 November 2016
- 年：2016
- 卷：17
- 期：7
- 页码：1858-1871
- 全文大小：3718 K
文摘
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Utilize BioID to profile the composition of telomeres in cancer cells
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DNA polymerase eta (Polη) localizes specifically to ALT telomeres
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Loss of Polη enhances ALT and promotes mitotic DNA synthesis at telomeres