[1,2]Oxazolo[5,4-e]isoindoles as promising tubulin polymerization inhibitors
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- 作者：Virginia Spanò ; a ; 1 ; Marzia Pennatib ; 1 ; Barbara Parrinoa ; Anna Carbonea ; Alessandra Montalbanoa ; Alessia Lopergolob ; Valentina Zucob ; Denis Cominettib ; Patrizia Dianaa ; Girolamo Cirrincionea ; Nadia Zaffaronib ; Paola Barrajaa ; paola.barraja@unipa.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：[1 ; 2]Oxazolo[5 ; 4-e]isoindoles ; α-hydroxyalkyl ketones ; Antitubulin agents ; Diffuse malignant peritoneal mesothelioma
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：29 November 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：840-851
- 全文大小：725 K
文摘
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A new series of [1,2]oxazolo[5,4-e]isoindoles were prepared by a versatile sequence.
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Remarkable and selective antiproliferative activity against DMPM.
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