ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation
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- 作者：Yuko Atsumi1 ; 2 ; Yusuke Minakawa1 ; 3 ; Masaya Ono4 ; Sachiko Dobashi1 ; Keitaro Shinohe5 ; Akira Shinohara6 ; Shunichi Takeda7 ; Masatoshi Takagi8 ; Nobuhiko Takamatsu2 ; Hitoshi Nakagama1 ; Hirobumi Teraoka5 ; Ken-ichi Yoshioka1 ; kyoshiok@ncc.go.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：29 December 2015
- 年：2015
- 卷：13
- 期：12
- 页码：2728-2740
- 全文大小：6042 K
文摘
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H2AX is degraded via poly-ubiquitination mediated by HUWE1
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H2AX is transiently stabilized upon DSB formation to efficiently form γH2AX foci
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H2AX stabilization is mediated by ATM, SIRT6, and SNF2H