Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma
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- 作者：Maymi Kato ; Koichi Ohshima ; Masahiro Mizuno ; Masahisa Kyogoku ; Keiko Hashikawa ; Yoshiki Tokura ; Yoshiki Miyachi ; Kenji Kabashima
- 关键词：chemokine ; chemokine receptor ; CXCL9 ; CXCR3 ; intravascular large B-cell lymphoma ; skin
- 刊名：Journal of the American Academy of Dermatology
- 出版年：2009
- 出版时间：November 2009
- 年：2009
- 卷：61
- 期：5
- 页码：888-891
- 全文大小：2972 K
文摘
Intravascular large B-cell lymphoma is a rare disease with multiorgan involvement that also affects the skin. Skin manifestations include purpuric to red macules, plaques, or nodules with occasional edema and tenderness. We report a 68-year-old woman with bilateral leg edema and occasional high fever. A biopsy specimen from a subcutaneous nodule showed that the blood vessels in the dermis and subcutaneous tissue were filled with irregularly shaped chromatin-rich large atypical lymphocytes positive for CD20 and bcl-2, consistent with the diagnosis of intravascular large B-cell lymphoma. In addition, immunohistochemical analysis showed expression of CXCR3 in the atypical lymphocytes; its ligand, CXCL9, was detected in blood vessels. Although limited to a single case, our study could provide a possible new clue to the pathogenesis of intravascular large B-cell lymphoma by virtue of the characteristic expression of CXCL9-CXCR3.