Synthetic study of strongylophorines: stereoselective construction of the characteristic lactone bridge
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- 作者：Yuya Oikawa&dagger ; ; Daiki Uchiyama&dagger ; ; Takuya Shirasawa ; Masato Oikawa ; Yuichi Ishikawa ; yu_iskw@yokohama-cu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Strongylophorines ; Meroditerpenoid ; Hypoxia inducible factor-1 ; C&ndash ; H functionalization ; δ-Lactone bridge
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：31 August 2016
- 年：2016
- 卷：57
- 期：35
- 页码：3949-3951
- 全文大小：493 K
文摘
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Strongylophorine-2 is a meroditerpenoid isolated from marine sponge, Strongylophora durissima.
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This compound is an inhibitor for HIF-1 transcriptional pathway.
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Oxidative C–H functionalization at the C24 methyl group proceeded smoothly.
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Construction of the C4 quaternary carbon stereogenic center was accomplished.
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The characteristic lactone bridge was constructed in a stepwise manner.