The present study examined the effects of activating GABA
A receptors in the anterior and posterior regions of the ventral tegmental area (VTA) on operant reinforcement behavior, using the technique of intracranial self-administration. Rats were given the opportunity to self-administer vehicle alone (artificial CSF) and vehicle containing 25, 50, and 100 μM muscimol, a GABA
A agonist, into the anterior or posterior VTA during four sessions (3 h/session) in standard two-lever operant chambers. Rats received five times greater infusions of 50 and 100 μM muscimol than vehicle into the posterior VTA; both doses significantly increased responding above vehicle levels on the active and inactive (control) levers equally. When the response requirement for muscimol infusions was increased from a fixed-ratio 1 (FR1) to FR3 in a single-lever chamber, the total session responses increased approximately twofold. Muscimol was not self-infused when cannula placements were in the anterior VTA. The self-infusion of muscimol into the posterior VTA was attenuated by coadministration of picrotoxin. Overall, the results suggest that the activation of GABA
A receptors in the posterior VTA produces goal-directed behavior.
Publisher: | Elsevier Science |
Language of Publication: | English |
Item Identifier: | S0091-3057(98)00086-0 |
Publication Type: | Article |
ISSN: | 0091-3057 |
Cited by: | - Ikemoto, Satoshi; Sharpe, Lawrence G.,""A head-attachable device for injecting nanoliter volumes of drug solutions into brain sites of freely moving rats""Journal of Neuroscience Methods2001pp. 135-140
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oisr mi"">Bibliographic Pageoisrmi&form=pdf&file=file.pdf"">Full Text |
| Footnotes: Present address: Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, 1501 Kings Highway, Shreveport, LA 71130–3932.
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