Regional Differences Within the Rat Ventral Tegmental Area for Muscimol Self-Infusions

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• 作者：Ikemoto ; Satoshi ; et. al.
• 关键词：Intracranial self-administration ; Reinforcement ; Muscimol ; GABA_A receptors ; Caudal linear nucleus ; Ventral tegmental area
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：1998
• 出版时间：September, 1998
• 年：1998
• 卷：61
• 期：1
• 页码：87-92
• 全文大小：164 K

文摘

The present study examined the effects of activating GABA_A receptors in the anterior and posterior regions of the ventral tegmental area (VTA) on operant reinforcement behavior, using the technique of intracranial self-administration. Rats were given the opportunity to self-administer vehicle alone (artificial CSF) and vehicle containing 25, 50, and 100 μM muscimol, a GABA_A agonist, into the anterior or posterior VTA during four sessions (3 h/session) in standard two-lever operant chambers. Rats received five times greater infusions of 50 and 100 μM muscimol than vehicle into the posterior VTA; both doses significantly increased responding above vehicle levels on the active and inactive (control) levers equally. When the response requirement for muscimol infusions was increased from a fixed-ratio 1 (FR1) to FR3 in a single-lever chamber, the total session responses increased approximately twofold. Muscimol was not self-infused when cannula placements were in the anterior VTA. The self-infusion of muscimol into the posterior VTA was attenuated by coadministration of picrotoxin. Overall, the results suggest that the activation of GABA_A receptors in the posterior VTA produces goal-directed behavior. Publisher: Elsevier Science Language of Publication: English Item Identifier: S0091-3057(98)00086-0 Publication Type: Article ISSN: 0091-3057 Cited by:

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Footnotes:

1. Present address: Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, 1501 Kings Highway, Shreveport, LA 71130–3932.