Passive immunization targeting the N-terminal region of phosphorylated tau (residues 68-71) improves spatial memory in okadaic acid induced tauopathy model rats

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• 作者：Sarada Subramanian ; ^{sarada@nimhans.ac.in} ; ^{saradabs@yahoo.com} ; Ganesh Savanur ; Sowmya Madhavadas
• 关键词：Okadaic acid ; Alzheimer disease ; Phosphopeptide ; Tau ; Spatial memory ; Tauopathy
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：585-589
• 全文大小：444 K
• 卷排序：483

文摘

Anti-phospho-tau peptide 50TPTEDGSEEPGSETSDAKpSpTPpT71 antibodies prevented aggregation of tau in vitro. Passive immunization of okadaic acid (OA) treated experimental rats with these antibodies improved spatial memory functions. Further, antibody treatment reduced the p-tau levels in the hippocampal homogenates of OA rats.