Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7-O-acyl okadaic acid
详细信息 查看全文
- 作者：Sachie Furumochia ; Tatsuya Onodaa ; Yuko Choa ; Haruhiko Fuwab ; Makoto Sasakib ; Mari Yotsu-Yamashitaa ; Keiichi Konokia ; konoki@m.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Okadaic acid ; Dinophysistoxin 3 ; Detoxification ; Bivalves
- 刊名：Bioorganic & Medicinal Chemistry Letters
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：26
- 期：13
- 页码：2992-2996
- 全文大小：1242 K
文摘
- •
In vitro acylation of OA was characterized for identifying the enzyme.
- •
Optimal carbon chain length in acyl CoA for the in vitro acylation was verified.
- •
Synthetic functional fatty acyl CoAs were substrates for the OA-acylating enzyme.
- •
LC-FLD could be favored over LC/MS for identifying the enzyme.