Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System
详细信息 查看全文
- 作者：Matteo M. Guerrini1 ; 2 ; Kazuo Okamoto1 ; 2 ; Noriko Komatsu1 ; Shinichiro Sawa1 ; 2 ; Lynett Danks1 ; 2 ; Josef M. Penninger3 ; Tomoki Nakashima4 ; 5 ; Hiroshi Takayanagi1 ; 2 ; takayana@m.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：43
- 期：6
- 页码：1174-1185
- 全文大小：4532 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
T cell-specific Tnfsf11 knockout mice are resistant to EAE
- class="label">•
RANKL-deficient T cells fail to efficiently infiltrate into the CNS
- class="label">•
T cells induce production of CCL20 by astrocytes through RANKL
- class="label">•
Pharmacological inhibition of RANKL prevents EAE