Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency
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- 作者：Asuka Terashima1 ; 2 ; Kazuo Okamoto1 ; 2 ; Tomoki Nakashima3 ; 4 ; 5 ; Shizuo Akira6 ; Koichi Ikuta7 ; Hiroshi Takayanagi1 ; takayana@m.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：21 June 2016
- 年：2016
- 卷：44
- 期：6
- 页码：1434-1443
- 全文大小：3518 K
文摘
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Sepsis reduces the number of osteoblasts and common lymphoid progenitors
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Inducible osteoblast ablation leads to T and B lymphopenia
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Osteoblast-derived IL-7 is required for development of common lymphoid progenitors
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Sepsis-induced immunodeficiency is ameliorated by osteoblast stimulation