Chromatin Constrains the Initiation and Elongation of DNA Replication

详细信息    查看全文

• 作者：Sujan Devbhandari¹ ; ² ; Jieqing Jiang¹ ; ² ; Charanya Kumar¹ ; Iestyn Whitehouse¹ ; Dirk Remus¹ ; ³ ; ^{remusd@mskcc.org}
• 关键词：DNA replication ; McM2-7 ; ORC ; DNA polymerase ; chromatin ; Okazaki fragment ; replication origin ; leading strand ; lagging strand
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：65
• 期：1
• 页码：131-141
• 全文大小：2045 K
• 卷排序：65

文摘

DNA replication has been reconstituted with 24 purified yeast proteins System recapitulates regulated origin firing and leading and lagging strand synthesis Nucleosomes limit Okazaki fragment length by blocking Pol δ progression Chromatin promotes origin dependence