Familial diffuse pulmonary ossification: A possible genetic disorder

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• 作者：Yoshiaki Kinoshita ; MD^a ; ^{yoshi-kino@umin.ac.jp} ; Ichiko Mizuguchi ; MD^b ; ^{icchikom@yahoo.co.jp} ; Kouko Hidaka ; MD ; PhD^b ; ^{hida@kokura2.hosp.go.jp} ; Hiroshi Ishii ; MD ; PhD^a ; ^{hishii@fukuoka-u.ac.jp} ; Kentaro Watanabe ; MD ; PhD^a ; ^{watanabe@fukuoka-u.ac.jp}
• 关键词：BMP ; bone morphogenetic protein ; DPO ; diffuse pulmonary ossification ; TGF-β ; transforming growth factor β
• 刊名：Respiratory Investigation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：55
• 期：1
• 页码：79-82
• 全文大小：1567 K
• 卷排序：55

文摘

Diffuse pulmonary ossification (DPO) is an uncommon disease that is characterized by the widespread formation of ectopic bone in the lungs. Herein, we describe two familial cases of DPO. The patients were a 47-year-old woman and her 76-year-old father. Both patients had a history of recurrent cough, and their chest images showed multiple nodules with ossification. No underlying diseases that might have caused DPO were evident; however, the female patient also had congenital finger hypoplasia and deformity. The present cases indicate the possibility that DPO might be partly associated with genetic disorders.