Synthesis of chalcones and flavanones using Julia–Kocienski olefination

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• 作者：Atul Kumar ; Siddharth Sharma ; Vishwa Deepak Tripathi ; Suman Srivastava
• 关键词：Chalcone ; Flavanones ; Julia– ; Kocienski olefination
• 刊名：Tetrahedron
• 出版年：2010
• 出版时间：27 November 2010
• 年：2010
• 卷：66
• 期：48
• 页码：9445-9449
• 全文大小：711 K

文摘

A new application of Julia–Kocienski olefination for the synthesis of chalcones and flavanones has been described. 2-(Benzo[d]thiazol-2-ylsulfonyl)-1-phenylethanones have been developed as new reagents for direct Julia–Kocienski olefination with aldehydes in the presence of a base, afforded chalcones in good to excellent yields. Whereas, 2-(benzo[d]thiazol-2-ylsulfonyl)-1-(2-hydroxyphenyl)ethanone reacted with the aromatic aldehydes to furnish flavanones in good yields via one-pot intra-molecular cyclization.