Enantioselective synthesis of the C5-C23 segment of biselyngbyaside

详细信息    查看全文

• 作者：Srivari Chandrasekhar ; ^{srivaric@iict.res.in} ; Gontla Rajesh ; Tumma Naresh
• 关键词：Biselyngbyaside ; Julia&ndash ; Kocienski olefination ; Crimmin&rsquo ; s acetate aldol reaction
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：16 January, 2013
• 年：2013
• 卷：54
• 期：3
• 页码：252-255
• 全文大小：620 K

文摘

Stereo and enantioselective synthesis of C5-C23 fragment of cytotoxic marine natural product biselyngbyaside is achieved using E-selective methyl lithium addition onto enyne, Crimmin¡¯s acetate aldol reaction, Sharpless asymmetric epoxidation, and Julia-Kocienski olefination as the key steps.