Stereoselective total synthesis of penaresidin A starting from d-galactal
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- 作者：B.V. Subba Reddy ; Ch. Kishore ; A. Srinivas Reddy
- 关键词：d-Galactal ; Asymmetric epoxidation ; Azetidine formation ; Jung&rsquo ; s protocol ; Julia&ndash ; Kocienski olefination
- 刊名：Tetrahedron Letters
- 出版年：1 January, 2014
- 年：2014
- 卷：55
- 期：1
- 页码：49-51
- 全文大小：600 K
文摘
A stereoselective total synthesis of penaresidin A has been accomplished involving Sharpless asymmetric epoxidation, regioselective ring-opening of epoxide, azetidine formation via SN2 reaction, Jung鈥檚 protocol, and Julia-Kocienski olefination. This approach has successfully demonstrated the synthetic utility of d-galactal in the construction of azetidine core of the natural product.