Synthesis of 3-oxadiazolyl/triazolyl morpholines: Novel scaffolds for drug discovery

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• 作者：Alexander D. Tereshchenko^a ; ^b ; Julia S. Myronchuk^a ; Lena D. Leitchenko^a ; Irina V. Knysh^e ; Ganna O. Tokmakova^e ; Olena O. Litsis^b ; Andrey Tolmachev^a ; ^c ; ^d ; Konstantin Liubchak^a ; ^{kliubchak@gmail.com} ; Pavel Mykhailiuk^a ; ^b ; ^c ; ^{pavel.mykhailiuk@gmail.com}
• 关键词：Anodic oxidation ; Oxadiazoles ; 1 ; 2 ; 4-Triazoles ; Morpholine ; Building blocks ; Drug discovery
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：9 February 2017
• 年：2017
• 卷：73
• 期：6
• 页码：750-757
• 全文大小：568 K
• 卷排序：73

文摘

Synthesis of isomeric 3-oxadiazolyl/triazolyl morpholines was performed based on a common intermediate on the gram scale. The target compounds were designed as novel scaffolds for the medicinal chemistry. The key reaction was an electrochemical CH-oxidation of N-Boc morpholine.