Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice
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- 作者：J. Tomas-Roiga ; b ; 1 ; jordi.tomas-roig@med.uni-goettingen.de" class="auth_mail" title="E-mail the corresponding author ; F. Piscitellic ; 2 ; V. Gild ; 2 ; J.A. del Rí ; od ; T.P. Moorea ; b ; H. Agbemenyahe ; f ; G. Salinas-Riesterg ; C. Pommerenkeg ; S. Lorenzenh ; i ; T. Beiß ; barthh ; S. Hoyer-Fenderj ; V. Di Marzoc ; U. Havemann-Reineckea ; b ; 1
- 关键词：HPA ; hypothalamo&ndash ; pituitary&ndash ; adrenal ; eCB ; endocannabinoid ; CB1 ; cannabinoid receptor type 1 ; THC ; Δ9-tetrahydrocannabinol ; AEA ; N-arachidonylethanolamine ; 2-AG ; 2-arachidonoylglycerol ; PEA ; palmitoylethanolamide ; OEA ; oleoylethanolamide ; ER ; endoplasmic reticulum ; UPR ; unfolded protein response ; PTSD ; post-traumatic stress disorder ; Calr ; calreticulin ; Zfp488 ; zinc finger protein 488 ; Hyou1 ; hypoxia up-regulated 1 ; Slc2a1 ; solute carrier family 2 (facilitated glucose transporter) memb
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：303
- 期：Complete
- 页码：34-43
- 全文大小：1209 K
文摘
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Motor coordination and motor learning are compromised in social defeat mice.
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After three weeks of social stress, the cerebellum of stressed mice compared to control non-stressed mice showed higher 2-AG concentration and lower CB1 mRNA and protein expression.
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Next Generation Sequencing revealed an increase in calreticulin expression after 3 weeks of chronic psychosocial stress.