Subretinal AAV2.COMP-Ang1 suppresses choroidal neovascularization and vascular endothelial growth factor in a murine model of age-related macular degeneration
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- 作者：Nathan G. Lamberta ; 1 ; Xiaohui Zhanga ; b ; 1 ; Ruju R. Raia ; b ; Hironori Ueharaa ; b ; Susie Choia ; b ; Lara S. Carrolla ; b ; Subrata K. Dasa ; b ; Judd M. Cahoona ; Brian H. Kirka ; Blaine M. Bentleya ; Balamurali K. Ambatia ; b ; bala.ambati@utah.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Age-related macular degeneration ; Choroidal neovascularization ; Vascular endothelial growth factor ; Cartilage oligomeric matrix protein ; Angiopoietin-1 ; Adeno-associated virus ; Subretinal injection
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：145
- 期：Complete
- 页码：248-257
- 全文大小：1818 K
文摘
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AAV2.COMP-Ang1 may be an efficacious therapy for neovascular AMD.
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Subretinal AAV2.COMP-Ang1 induces COMP-Ang1 protein expression in the RPE/choroid.
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Subretinal AAV2.COMP-Ang1 suppresses laser-induced VEGF protein expression in the RPE/choroid.
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Subretinal AAV2.COMP-Ang1 reduces laser-induced CNV volume.