Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence
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- 作者：Meili Wanga ; b ; Yi Fua ; b ; Cheng Gaoa ; b ; Yiting Jiaa ; b ; Yaqian Huangc ; Limei Liua ; Xian Wanga ; b ; Wengong Wangd ; Wei Konga ; b ; kongw@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vascular extracellular matrix protein ; COMP ; Vascular aging ; VSMC senescence
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：16 September 2016
- 年：2016
- 卷：478
- 期：2
- 页码：1006-1013
- 全文大小：1405 K
文摘
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Expand understanding of ECM in maintaining vascular homeostasis through inhibition of vascular aging.
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COMP protein is downregulated in aortas of different aging mouse models.
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Endogenous COMP retards vascular aging and aging-related vascular dysfunction.
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COMP inhibits vascular smooth muscle cells senescence.