Impact of donor binding on polymerization catalyzed by KfoC by regulating the affinity of enzyme for acceptor
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- 作者：Jiajun Xuea ; Lan Jinb ; Xinke Zhanga ; Fengshan Wanga ; b ; Peixue Lingc ; ; Juzheng Shenga ; b ; shengjuzheng@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Carbohydrate biosynthesis ; Glycosaminoglycan ; Chondroitin polymerase ; Substrate specificity ; Catalytic mechanism
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1860
- 期：4
- 页码：844-855
- 全文大小：1979 K
文摘
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KfoC has broad donor substrate specificity and acceptor promiscuity.
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KfoC is an attractive tool enzyme in chimeric glycosaminoglycan oligosaccharide synthesis.
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We examine the regulating role of donor binding on polymerization of KfoC.