Automated fluorous-assisted solution-phase synthesis of β-1,2-, 1,3-, and 1,6-mannan oligomers
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- 作者：Shu-Lun Tanga ; Nicola L.B. Pohla ; b ; npohl@indiana.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Automated oligosaccharide synthesis ; β-Mannan ; β-Mannuronate ; Fluorous-assisted synthesis
- 刊名：Carbohydrate Research
- 出版年：2016
- 出版时间：22 July 2016
- 年：2016
- 卷：430
- 期：Complete
- 页码：8-15
- 全文大小：824 K
文摘
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Automated flourous-assisted solution-phase synthesis of β-1,2-, 1,3-, and 1,6-mannopyranoside linkages with mannuronate donors.
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Use of the β-directing C-5 ester of mannuronate donors as a protecting group that can support the automated synthesis of short β-1,6-mannan oligomers.
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Demonstrating removal of soluble F-tagged intermediates for analysis and/or purification and subsequent return to the automated synthesis platform for further reactions.
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Fewer equivalents of glycosyl donors were needed for each glycosylation cycle than related solid-phase-based protocols.