Glycosylation Quality Control by the Golgi Structure
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- 作者：Xiaoyan Zhang1 ; Yanzhuang Wang1 ; 2 ; yzwang@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CDG ; congenital disorders of glycosylation ; COG ; conserved oligomeric Golgi ; ER ; endoplasmic reticulum ; GAG ; glycosaminoglycan ; GlcNAc ; β-N-acetylglucosamine ; LLO ; lipid-linked oligosaccharide ; RNAi ; RNA interference ; TGN ; trans-Golgi network
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：14 August 2016
- 年：2016
- 卷：428
- 期：16
- 页码：3183-3193
- 全文大小：631 K
文摘
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The Golgi is the central organelle for protein trafficking and glycosylation.
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GRASPs play essential roles in Golgi structure formation.
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Golgi stack formation decelerates protein trafficking.
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Golgi stack formation ensures accurate protein glycosylation.
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COGs target glycosylation enzymes to the precise locations in the Golgi stack.