Flipping a Lipid-Linked Oligosaccharide? You Must Whip It!

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• 作者：Mark A. Lehrman¹ ; ^{mark.lehrman@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：polyisoprenol ; undecaprenol ; dolichol ; lipid-linked oligosaccharide ; flippase
• 刊名：Trends in Biochemical Sciences
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：40
• 期：12
• 页码：715-717
• 全文大小：400 K

文摘

The mechanism for flipping large lipid-linked oligosaccharides across membranes has remained a paradox. Perez et al. now report the structure of the PglK protein of C. jejuni, a flippase for a bacterial lipid-linked oligosaccharide, and reveal an unexpected whip-like mechanism.