Genotoxic and mutagenic effects of fipronil on mice

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• 作者：Patr¨ªcia Rosa de Oliveira ; Gerv¨¢sio Henrique Bechara ; S ; ra Eloisi Denardi ; Rodrigo Juliano Oliveira ; Maria Izabel Camargo Mathias
• 关键词：Fipronil ; Pesticide ; Micronucleus ; Comet ; Mice
• 刊名：Experimental and Toxicologic Pathology
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：64
• 期：6
• 页码：569-573
• 全文大小：246 K

文摘

The toxic effects of several compounds on ecosystems are not restricted to ecological disturbances, and may also affect long-term human health. Fipronil is highly efficient in the control of pests, including those resistant to pyrethroid, organophosphate, and carbamate insecticides. Relatively little is known about the action of fipronil in vertebrates. This study was aimed to evaluate the genotoxic and mutagenic potential of this compound in mice exposed to different doses and demonstrates the damage caused by fipronil on non-target organisms in artificial conditions. Mice were divided into five groups: group I = 30 % of DL₅₀ (15 mg/kg), group II = 50 % of the DL₅₀ (25 mg/kg), group III = DL₅₀ (50 mg/kg), group IV = negative control, and group V = positive control. Peripheral blood was collected for the comet assay (24 h after exposure) and the micronucleus test (24, 48 and 72 h after exposure). Our findings revealed that doses of 15 mg/kg (group I) and 25 mg/kg (group II) of fipronil did not have genotoxic or mutagenic effects. Only the highest dose tested (50 mg/kg) induced DNA damage 24 h after exposure, indicating the mutagenic potential of fipronil. Therefore, this or higher doses are not recommended, as they may be toxic to non-target organisms.