Which features of advanced head and neck basal cell carcinoma are associated with perineural invasion?
详细信息 查看全文
- 作者：André ; Bandiera de Oliveira Santos ; andre_bandiera@yahoo.com.br ; Natá ; lia Martins Magacho de Andrade ; Lenine Garcia Brandã ; o ; Claudio Roberto Cernea
- 关键词：Perineural invasion ; Basal cell carcinoma ; Head and neck
- 刊名：Brazilian Journal of Otorhinolaryngology
- 出版年：2017
- 出版时间：January-February 2017
- 年：2017
- 卷：83
- 期：1
- 页码：94-97
- 全文大小：357 K
- 卷排序：83
文摘
Perineural invasion is a unique route for tumor dissemination. In basal cell carcinomas, the incidence is low, but increases in advanced cases. Its importance is recognized but not fully understood.ObjectiveTo compare head and neck basal cell carcinomas with and without perineural invasion.MethodsA retrospective medical chart review of multidisciplinary surgeries for basal cell carcinomas that required a head and neck surgery specialist in a tertiary referral center was performed. Clinical-demographics and histopathological features were analyzed.ResultsOf 354 cases, perineural invasion was present in 23.1%. Larger tumors and morpheaform subtype were statistically related to perineural invasion. Nodular and superficial subtypes were less frequent in positive cases. No significant difference was found in gender, age, ulceration, location, and mixed histology.ConclusionIn this series of selected patients with basal cell carcinomas submitted to major resections, perineural invasion was clearly related to morpheaform subtype and to larger tumors. Other classically associated features, such as location in high-risk mask zone of the face, male gender and mixed histology, were not so strongly linked to perineural invasion.