Synthesis and in vitro Trichomonacidal activities of some new dialkylperoxides and 1,2,4-trioxanes

详细信息    查看全文

• 作者：Camuzat-Dedenis ; Boris ; Provot ; Olivier ; Cointeaux ; Laure ; Perroux ; Viviane ; Berrien ; Jean-Franç ; ois ; et. al.
• 关键词：peroxides ; Trichomonas vaginalis ; metronidazole ; trioxanes
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2001
• 出版时间：October, 2001
• 年：2001
• 卷：36
• 期：10
• 页码：837-842
• 全文大小：101 K

文摘

Two series of three trioxanes and 18 disubstituted peroxides were synthesised and evaluated for their in vitro trichomonacidal activity against Trichomonas vaginalis. The most active compound, 2-methylprop-2-yl 2-methoxyeth-1-yl peroxide exhibited an IC₅₀ value of 1.0±0.2 μM whereas other dialkyl peroxides had various IC₅₀ values which could not be correlated to their molecule structure. The best compound was about five times more active than metronidazole. The amount of generated oxygen or free radicals cannot explain completely the activity suggesting another way of action for these compounds on T. vaginalis.