Immunity to hepatitis A and B persists for at least 15 years after immunisation of adolescents with a combined hepatitis A and B vaccine
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- 作者：Jiri Berana ; Olivier Van Der Meerenb ; olivier.x.van-der-meeren@gsk.com" class="auth_mail" title="E-mail the corresponding author ; Maarten Leyssenb ; Priya D'silvac
- 关键词：HAV ; hepatitis A virus ; HBV ; hepatitis B virus ; HBs ; hepatitis B surface antigen ; anti-HBs ; antibodies to hepatitis B surface antigen ; anti-HAV ; antibodies to hepatitis A virus ; ATP ; according-to-protocol ; CI ; confidence interval ; CLIA ; chemiluminescence immunosorbent assay ; ELISA ; enzyme-linked immunosorbent assay ; GMC ; geometric mean concentration ; IU ; International units ; LT-ATP ; long-term-according to protocol ; EL.U ; ELISA Units
- 刊名：Vaccine
- 出版年：2016
- 出版时间：23 May 2016
- 年：2016
- 卷：34
- 期：24
- 页码：2686-2691
- 全文大小：1493 K
文摘
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2- and 3-dose combined hepatitis A and B vaccination imparts immunity for ≥15 years.
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All subjects remained seropositive for anti-HAV; 81% were protected for anti-HBs.
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One-month post-challenge, all except one subject in the 3-dose group showed a robust anamnestic response.
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High anamnestic response suggests no need for booster dosing for ≥15 years.