ABC-cassette transporter 1 (ABCA1) expression in epithelial cells in?Chlamydia pneumoniae infection
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- 作者：Juha T. Korhonen ; Vesa M. Olkkonen ; Riitta Lahesmaa ; Mirja Puolakkainen
- 关键词：Chlamydia pneumoniae ; ABCA1 ; Epithelial cells
- 刊名：Microbial Pathogenesis
- 出版年：2013
- 出版时间：August-September, 2013
- 年：2013
- 卷：61-62
- 期：Complete
- 页码：57-61
- 全文大小：644 K
文摘
ATP-binding cassette transporter A1 (ABCA1) mediates reverse cholesterol transport and innate immunity response in different cell types. We have investigated the regulation of ABCA1 expression in response to intracellular m>Chlamydia pneumoniae m> infection in A549 epithelial lung carcinoma cells.?m>C.?pneumoniae m> infection decreased ABCA1 expression in A549 cells, and the activity of the ABCA1 promoter was decreased. The decreased promoter activity was dependent on its E-box and GnT-box elements of the promoter. Chlamydial growth was decreased in ABCA1-silenced epithelial lung carcinoma cells. These data indicate an important role for ABCA1 in intracellular bacterial infection.