Multiple sclerosis relapses are associated with increased fatigue and reduced health-related quality of life - A post hoc analysis of the TEMSO and TOWER studies
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- 作者：Mathias Mä ; urera ; mathias.maeurer@ckbm.de" class="auth_mail" title="E-mail the corresponding author ; Giancarlo Comib ; comi.giancarlo@hsr.it" class="auth_mail" title="E-mail the corresponding author ; Mark S. Freedmanc ; mfreedman@toh.on.ca" class="auth_mail" title="E-mail the corresponding author ; Ludwig Kapposd ; lkappos@uhbs.ch" class="auth_mail" title="E-mail the corresponding author ; Tomas P. Olssone ; tomas.olsson@ki.se" class="auth_mail" title="E-mail the corresponding author ; Jerry S. Wolinskyf ; jerry.s.wolinsky@uth.tmc.edu" class="auth_mail" title="E-mail the corresponding author ; Aaron E. Millerg ; aaron.miller@mssm.edu" class="auth_mail" title="E-mail the corresponding author ; Catherine Dive-Poulettyh ; catherine.dive-pouletty@sanofi.com" class="auth_mail" title="E-mail the corresponding author ; Sylvie Bozzih ; sylvie.bozzi@sanofi.com" class="auth_mail" title="E-mail the corresponding author ; Paul W. O&rsquo ; Connori ; oconnorp@smh.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARR ; annualized relapse rate ; EDSS ; Expanded Disability Status Scale ; FIS ; fatigue impact scale ; FS ; functional system ; HRQoL ; health-related quality of life ; MCS ; (short form 36) mental health component summary ; MID ; minimally important difference ; PCS ; (short form 36) physical health component summary ; QoL ; quality of life ; SF-6D ; short form 6-dimension ; SF-36 ; short form 36
- 刊名：Multiple Sclerosis and Related Disorders
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：7
- 期：Complete
- 页码：33-40
- 全文大小：1717 K
文摘
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We used data from >900 MS patients from the TEMSO and TOWER teriflunomide trials.
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Patient-reported health-related quality of life (HRQoL) and fatigue were assessed.
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We used four definitions to identify severe MS relapses.
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Some 420 patients had relapse(s); most met at least one definition of severe relapse.
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Patients experiencing severe relapse(s) had worsening in fatigue and HRQoL