Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis
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- 作者：Sandra Hellberg1 ; 8 ; Daniel Eklund1 ; 8 ; daniel.eklund@liu.se" class="auth_mail" title="E-mail the corresponding author ; Danuta R. Gawel2 ; Mattias Kö ; psé ; n2 ; 3 ; Huan Zhang2 ; Colm E. Nestor2 ; Ingrid Kockum4 ; Tomas Olsson4 ; Thomas Skogh5 ; Alf Kastbom5 ; Christopher Sjö ; wall5 ; Magnus Vrethem6 ; Irene Hå ; kansson6 ; Mikael Benson2 ; Maria C. Jenmalm1 ; Mika Gustafsson3 ; 9 ; mika.gustafsson@liu.se" class="auth_mail" title="E-mail the corresponding author ; Jan Ernerudh7
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：16
- 期：11
- 页码：2928-2939
- 全文大小：2500 K
文摘
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Dynamic CD4+ T cell responses in vitro revealed a dysregulated network module in MS
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This module was highly enriched for GWAS genes and translated into protein expression
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A combined protein score readily predicted disease activity and treatment response
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Integrating GWASs with dynamic expression profiling disclosed personalized biomarkers